Hey！🔥Welcome to Runhang’s base🔥

  I obtained my M.S. focusing #insect#microbe#nutrtion#behavior at the Univ. of Florida at Wong lab. Now, I am a 1st-year Ph.D student at UCI CMB program. I was co-advised by Katrine Whiteson and Charles Glabe for the rotation during Fall 2021. I later rotaed in Albert Siryaporn lab and joined the lab! Currently, I am focusing on Pseudomonas phages and lysogen competition.

Research interests

Do microbe modulate our behavior? We are living a microbial world where all animals are intimately associated with microbes. The animal hosts have co-evolved with the microbes inhabiting in their body (i.e. gut). While human genome is hard to edit, the gut microbial community and its collective genetic materials are easy to amend through diet (prebiotics) and probiotics (dietary beneficial microbes), providing novel tactcics to improve human health. Given the epidemic of obesity worldwide and high sugar diet-shaped gut microbiome that could alter our feeding behavior, my goal is to use Drosophila model to illunimate the underlying mechanisms of microbiome-mediated host physiology (e.g. nutritional state and appetite).

Microbiome ecology. To translate the study of experimental models into clinical practice (Lactobacillus represents a good example), we have to study microbiome ecology! Our understanding of microbiome ecology is extremely limited such as gut microbial community is composed of >1000 bacterial taxa (some fungi&virus). It remains largely unknown whether the interactions of such an intricated network are highly personalized or universal across human. Furthermore, despite the gut microbiome intrapersonal variation is smaller than that of interpersonal variation, two sets of microbiome could exert similar functions, as known as functional redundancy of microbiome. The functional redundancy of the gut microbiome adds another layer of complexity to gut microbiome ecology. There is an urgent call for multi-disciplinary collaborations in microbiome study across different systems (soil, ocean, plant, animals). On top of continuous efforts in sequencing, bacteria genome editing, and clinic trails, I believe, mathematical modeling and simulation can provide great insights about designing a personalized microbial cocktail for human health.

Microbiome and host epigenome. Microbe and human share very similar langugae in the epigenetic modifications. Besides, many of microbiome-derived metabolites are involved in the biological process of epigenetic programming. The role of the cross-kingdom communication in driving many diseases including cancer has been unfolding. My goal is to apply computational tools to identify microbiome-associated links between epigenetic markers and diseases. These epigenetic markers and microbiome signature provide both cancer early diagosis and potential microbiome-based treatments.

Advocation

• “Understanding how microbes affect health and the biosphere requires an international initiative” - Nicole Dubilier, Margaret McFall-Ngai, and Liping Zhao

• Transparent datasets and transparent methodology are fundamental for the advancement of science.

• “Science not communicated is science not done” - Mellisa Marshall

We all love science and cherish that this is the greatest time to do science. Importantly, we should also TALK about science, SHARE ideas, and keep CRITICIZing.

  Here, I will log my thoughts on general science and my research field. The website will witness my personal progress and the development of my own research philosophy and life philosophy.

 感谢🙏来访

  故科学者，神圣之光，照世界者也，可以遏末流而生感动。- 鲁迅

  关于生物信息，我还在探索。后期我会多分析关于生信的小文章。敬请期待～